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Exocyclic DNA Adducts as Biomarkers of Lipid Oxidation and Predictors of Disease. Challenges in Developing Sensitive and Specific Methods for Clinical Studies

23 Jan 2009

Abstract excerpt

Exocyclic DNA adducts are emerging as potential new tools for the study of oxidative stress-related diseases as well as the determination of cancer etiology and cancer risk. It is important to determine whether levels of exocyclic DNA adducts reflect redox stress in vivo and what role these adducts play in human diseases. To answer these important questions, interindividual differences, tissue distribution,...

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PMID: 19166334
DOI: 10.1021/tx800367d

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