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Article

A WFS1 haplotype consisting of the minor alleles of rs752854, rs10010131, and rs734312 shows a protective role against type 2 diabetes in Russian patients.

The review of diabetic studies : RDS - 1 Jan 2010

Chistiakov Dimitry A, Khodyrev Dmitry S, Smetanina Svetlana A, Bel'chikova Larisa N, Suplotova Lyudmila A, Nosikov Valery V

Abstract excerpt

BACKGROUND: Rare variants of the WFS1 gene encoding wolframin cause Wolfram syndrome, a monogenic disease associated with diabetes insipidus, diabetes mellitus, optic atrophy, and deafness. In contrast, common variants of WFS1 showed association with type 2 diabetes (T2D) in numerous Caucasian po...

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Identifiers

PMID: 21713316
DOI: 10.1900/RDS.2010.7.285
PMCID: PMC3143543

Genes

WFS1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-21713316-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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A WFS1 haplotype consisting of the minor alleles of rs752854, rs10010131, and rs734312 shows a protective role against type 2 diabetes in Russian patients.PMID 21713316Read ↗

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Detailed investigation of the role of common and low-frequency WFS1 variants in type 2 diabetes risk.Semantic proximity Read ↗

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Association studies of genetic variation in the WFS1 gene and type 2 diabetes in U.K. populations.Semantic proximity Read ↗

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