Article
Association studies of genetic variation in the WFS1 gene and type 2 diabetes in U.K. populations.
Diabetes - 1 Apr 2002
Minton Jayne A L, Hattersley Andrew T, Owen Katharine, McCarthy Mark I, Walker Mark, Latif Farida, Barrett Timothy, Frayling Timothy M
Abstract excerpt
Mutations in the WFS1 gene cause beta-cell death, resulting in a monogenic form of diabetes known as Wolfram syndrome. The role of variation in WFS1 in type 2 diabetes susceptibility is not known. We sequenced the WFS1 gene in 29 type 2 diabetic probands and identified 12 coding variants. We used 152 parent-offspring trios to look for familial association; the R allele at residue 456 (P = 0.04) and the H allele...
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