Article
Genetic variations in the WFS1 gene in Japanese with type 2 diabetes and bipolar disorder.
Molecular genetics and metabolism - 1 Jul 2004
Kawamoto Takanori, Horikawa Yukio, Tanaka Takeshi, Kabe Noriko, Takeda Jun, Mikuni Masahiko
Abstract excerpt
Diabetic and psychiatric symptoms often appear in patients with Wolfram syndrome, and obligate carriers of WFS1 have increased prevalence of type 2 diabetes and are more likely to require hospitalization for psychiatric illness including bipolar disorder. To identify the polymorphisms in Japanese, we examined a region of approximately 50 kb covering the entire WFS1 gene, and evaluated the patterns of linkage...
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