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Article

Detailed investigation of the role of common and low-frequency WFS1 variants in type 2 diabetes risk.

Diabetes - 1 Mar 2010

Fawcett Katherine A, Wheeler Eleanor, Morris Andrew P, Ricketts Sally L, Hallmans Göran, Rolandsson Olov, Daly Allan, Wasson Jon, Permutt Alan, Hattersley Andrew T, Glaser Benjamin, Franks Paul W, McCarthy Mark I, Wareham Nicholas J, Sandhu Manjinder S, Barroso Inês

Abstract excerpt

OBJECTIVE: Wolfram syndrome 1 (WFS1) single nucleotide polymorphisms (SNPs) are associated with risk of type 2 diabetes. In this study we aimed to refine this association and investigate the role of low-frequency WFS1 variants in type 2 diabetes risk. RESEARCH DESIGN AND METHODS: For fine-mapping, we sequenced WFS1 exons, splice junctions, and conserved noncoding sequences in samples from 24 type 2 diabetic case...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 20028947
DOI: 10.2337/db09-0920
PMCID: PMC2828659

Genes

WFS1
MAF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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