Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Testing of diabetes-associated WFS1 polymorphisms in the Diabetes Prevention Program.

Diabetologia - 1 Mar 2008

Florez J C, Jablonski K A, McAteer J, Sandhu M S, Wareham N J, Barroso I, Franks P W, Altshuler D, Knowler W C

Abstract excerpt

AIMS/HYPOTHESIS: Wolfram syndrome (diabetes insipidus, diabetes mellitus, optic atrophy and deafness) is caused by mutations in the WFS1 gene. Recently, single nucleotide polymorphisms (SNPs) in WFS1 have been reproducibly associated with type 2 diabetes. We therefore examined the effects of these variants on diabetes incidence and response to interventions in the Diabetes Prevention Program (DPP), in which a...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Blood Glucose
Share to Diabetes Mellitus
Share to Diabetes Mellitus, Type 2

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Glucose Tolerance Test

Share to Linkage Disequilibrium

Share to Membrane Proteins

Share to Polymorphism, Genetic

Share to Polymorphism, Single Nucleotide

Source

Open in PubMed Open full text

Identifiers

PMID: 18060660
DOI: 10.1007/s00125-007-0891-x
PMCID: PMC2483955

Genes

WFS1

Variants

rs10010131

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Testing of diabetes-associated WFS1 polymorphisms in the Diabetes Prevention Program.PMID 18060660Read ↗

A WFS1 haplotype consisting of the minor alleles of rs752854, rs10010131, and rs734312 shows a protective role against type 2 diabetes in Russian patients.Semantic proximity Read ↗

Replication of the association between variants in WFS1 and risk of type 2 diabetes in European populations.Semantic proximity Read ↗

Autosomal Dominant Diabetes Arising From a Wolfram Syndrome 1 MutationSemantic proximity Read ↗

Association study of the effect of WFS1 polymorphisms on risk of type 2 diabetes in Japanese population.Semantic proximity Read ↗

Impact of polymorphisms in WFS1 on prediabetic phenotypes in a population-based sample of middle-aged people with normal and abnormal glucose regulation.Semantic proximity Read ↗

Detailed investigation of the role of common and low-frequency WFS1 variants in type 2 diabetes risk.Semantic proximity Read ↗

Common variants in WFS1 confer risk of type 2 diabetes.Semantic proximity Read ↗

Association of rs734312 and rs10010131 polymorphisms in WFS1 gene with type 2 diabetes mellitus: a meta-analysis.Semantic proximity Read ↗

Association studies of genetic variation in the WFS1 gene and type 2 diabetes in U.K. populations.Semantic proximity Read ↗

Decreased insulin secretion and increased risk of type 2 diabetes associated with allelic variations of the WFS1 gene: the Data from Epidemiological Study on the Insulin Resistance Syndrome (DESIR) prospective study.Semantic proximity Read ↗

WFS1 Gene-associated Diabetes Phenotypes and Identification of a Founder Mutation in Southern India.Semantic proximity Read ↗

Extension of type 2 diabetes genome-wide association scan results in the diabetes prevention program.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.