Article
Micro-RNA Binding Site Polymorphisms in the WFS1 Gene Are Risk Factors of Diabetes Mellitus.
PloS one - 1 Jan 2015
Elek Zsuzsanna, Németh Nóra, Nagy Géza, Németh Helga, Somogyi Anikó, Hosszufalusi Nóra, Sasvári-Székely Mária, Rónai Zsolt
Abstract excerpt
The absolute or relative lack of insulin is the key factor in the pathogenesis of diabetes mellitus. Although the connection between loss of function mutations of the WFS1 gene and DIDMOAD-syndrome including diabetes mellitus underpins the significance of wolframin in the pathogenesis, exact role of WFS1 polymorphic variants in the development of type 1 and type 2 diabetes has not been discovered yet. In this...
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