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Article

Novel WFS1 variants are associated with different diabetes phenotypes

16 Aug 2024

Abstract excerpt

Background The WFS1 gene encodes the protein wolframin, which is crucial for maintaining endoplasmic reticulum homeostasis. Variants in this gene are predominantly associated with Wolfram syndrome and have been implicated in other disorders such as diabetes mellitus and psychiatric diseases, which increases the rate of clinical misdiagnosis. Methods Patients were diagnosed with early-onset unclassified diabetes...

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PMID: 39221226
DOI: 10.3389/fgene.2024.1433060

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