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Article

Osteoradionecrosis in head-and-neck cancer has a distinct genotype-dependent cause.

International journal of radiation oncology, biology, physics - 15 Mar 2012

Lyons Andrew J, West Catharine M, Risk Janet M, Slevin Nick J, Chan Clara, Crichton Siobhan, Rinck Gabrielle, Howell Dawn, Shaw Richard J

Abstract excerpt

PURPOSE: We performed a case-control study to establish whether the development of osteoradionecrosis (ORN) was related to a variant allele substituting T for C at -509 of the transforming growth factor-β1 gene (TGF-β1). PATIENTS AND METHODS: A total of 140 patients, 39 with and 101 without ORN, who underwent radiotherapy for head-and-neck cancer with a minimum of 2 years follow-up, were studied. None of the...

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PMID: 21708430
DOI: 10.1016/j.ijrobp.2011.05.016

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