Cysteine mutants of herpes simplex virus type 1 glycoprotein D exhibit temperature-sensitive properties in structure and function.

doi:10.1128/JVI.64.11.5542-5552.1990

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Article

Cysteine mutants of herpes simplex virus type 1 glycoprotein D exhibit temperature-sensitive properties in structure and function.

Journal of virology - 1 Nov 1990

Long D, Cohen G H, Muggeridge M I, Eisenberg R J

Abstract excerpt

We previously constructed seven mutations in the gene for glycoprotein D (gD) of herpes simplex virus type 1 in which the codon for one of the cysteine residues was replaced by a serine codon. Each of the mutant genes was cloned into a eucaryotic expression vector, and the proteins were transient...

Topics

Animals
Antigens, Viral
Biological Transport
Cells, Cultured
Chlorocebus aethiops
Cysteine
DNA Mutational Analysis
Disulfides
Fluorescent Antibody Technique
Genetic Complementation Test
Mutation
Neutralization Tests

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Protein Binding

Protein Conformation

Protein Processing, Post-Translational

Simplexvirus

Structure-Activity Relationship

Temperature

Source

Open in PubMed Open full text

Identifiers

PMID: 2170686
DOI: 10.1128/JVI.64.11.5542-5552.1990
PMCID: PMC248606

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-2170686-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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