Deglycosylation of the NS1 protein of dengue 2 virus, strain 16681: construction and characterization of mutant viruses.

doi:10.1007/s00705-004-0430-8

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Article

Deglycosylation of the NS1 protein of dengue 2 virus, strain 16681: construction and characterization of mutant viruses.

Archives of virology - 1 Apr 2005

Crabtree M B, Kinney R M, Miller B R

Abstract excerpt

The dengue 2 virus (DENV-2) NS1 glycoprotein contains two potential sites for N-linked glycosylation at Asn-130 and Asn-207. NS1 produced in infected cells is glycosylated at both of these sites. We used site-directed mutagenesis of a DENV-2, strain 16681, full length infectious clone to create mutant viruses lacking the Asn-130, Asn-207 or both of these NS1 glycosylation sites in order to investigate the effects...

Topics

Aedes
Amino Acid Sequence
Animals
Antigens, Viral
Base Sequence
Cell Line
Dengue
Dengue Virus
Glycosylation
Mice
Mice, Inbred ICR
Phenotype
Viral Nonstructural Proteins
Virus Replication

Source

Open in PubMed

Identifiers

PMID: 15592895
DOI: 10.1007/s00705-004-0430-8

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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