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Article

Structure-based mutagenesis of herpes simplex virus glycoprotein D defines three critical regions at the gD-HveA/HVEM binding interface.

Journal of virology - 1 Jul 2003

Connolly Sarah A, Landsburg Daniel J, Carfi Andrea, Wiley Don C, Cohen Gary H, Eisenberg Roselyn J

Abstract excerpt

Herpes simplex virus (HSV) entry into cells requires the binding of glycoprotein D (gD) to one of several cell surface receptors. The crystal structure of gD bound to one of these receptors, HveA/HVEM, reveals that the core of gD comprises an immunoglobulin fold flanked by a long C-terminal extension and an N-terminal hairpin loop. HveA is a member of the tumor necrosis factor receptor family and contains four...

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Identifiers

PMID: 12829851
DOI: 10.1128/jvi.77.14.8127-8140.2003
PMCID: PMC161942

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Source receipt: pubmed, retrieved 7 Sept 2026.

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