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Article

An HSV-1 gD mutant virus as an entry-impaired live virus vaccine.

Vaccine - 26 Feb 2008

Awasthi Sita, Lubinski John M, Eisenberg Roselyn J, Cohen Gary H, Friedman Harvey M

Abstract excerpt

HSV-1 glycoprotein D (gD) interacts with HVEM and nectin-1 cell receptors to initiate virus entry. We prepared an HSV-1 strain with mutations in the gD gene at amino acid residues 3 and 38 by changing alanine to cysteine and tyrosine to cysteine, respectively (A3C/Y38C). These mutations were constructed with the intent of evaluating infection in vivo when virus enters by HVEM but not nectin-1 receptors and were...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 18243431
DOI: 10.1016/j.vaccine.2007.12.032
PMCID: PMC2680698

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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