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Article

PKCα mediates acetylcholine-induced activation of TRPV4-dependent calcium influx in endothelial cells.

American journal of physiology. Heart and circulatory physiology - 1 Sept 2011

Adapala Ravi K, Talasila Phani K, Bratz Ian N, Zhang David X, Suzuki Makoto, Meszaros J Gary, Thodeti Charles K

Abstract excerpt

Transient receptor potential vanilloid channel 4 (TRPV4) is a polymodally activated nonselective cationic channel implicated in the regulation of vasodilation and hypertension. We and others have recently shown that cyclic stretch and shear stress activate TRPV4-mediated calcium influx in endothelial cells (EC). In addition to the mechanical forces, acetylcholine (ACh) was shown to activate TRPV4-mediated calcium...

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Source

Open in PubMed Open full text

Identifiers

PMID: 21705673
DOI: 10.1152/ajpheart.00142.2011
PMCID: PMC3302191

Genes

TRPV4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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