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Article

TPL2 kinase regulates the inflammatory milieu of the myeloma niche

11 Apr 2014

Abstract excerpt

Targeted modulation of microenvironmental regulatory pathways may be essential to control myeloma and other genetically/clonally heterogeneous cancers. Here we report that human myeloma-associated monocytes/macrophages (MAM), but not myeloma plasma cells, constitute the predominant source of interleukin-1β (IL-1β), IL-10, and tumor necrosis factor-α at diagnosis, whereas IL-6 originates from stromal cells and...

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PMID: 24723682
DOI: 10.1182/blood-2014-02-554071

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