Loss of high affinity transforming growth factor-beta 1 (TGF-beta 1) binding to a nephritogenic T cell results in absence of growth inhibition by TGF-beta 1 and augmented nephritogenicity.

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Article

Loss of high affinity transforming growth factor-beta 1 (TGF-beta 1) binding to a nephritogenic T cell results in absence of growth inhibition by TGF-beta 1 and augmented nephritogenicity.

Journal of immunology (Baltimore, Md. : 1950) - 15 Apr 1996

Bailey N C, Frishberg Y, Kelly C J

Abstract excerpt

Transforming growth factor-beta (TGF-beta) affects cellular proliferation and differentiation and has been linked to the development of pathologic extracellular matrix production characteristic of progressive renal disease. TGF-beta 1 is conventionally regarded as having growth-inhibitory activit...

Topics

Amino Acid Sequence
Animals
Base Sequence
Binding Sites
Clone Cells
Growth Inhibitors
Immunity, Innate
Immunosuppressive Agents
Mice
Mice, Inbred Strains
Molecular Sequence Data
Mutation
Nephritis, Interstitial
T-Lymphocytes
Transforming Growth Factor beta

Source

Open in PubMed

Identifiers

PMID: 8609423

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8609423-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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