Article
Common FLG mutation K4671X not associated with atopic dermatitis in Han Chinese in a family association study.
PloS one - 1 Jan 2012
Cheng Ruhong, Li Ming, Zhang Hui, Guo Yifeng, Chen Xilan, Tao Jianfeng, Jiang Aifang, Gan Jiecheng, Qi Huaishan, Yu Hong, Liao Wanqing, Yao Zhirong
Abstract excerpt
BACKGROUND: Filaggrin gene (FLG) mutations have been identified as the cause of ichthyosis vulgaris (IV) and major predisposing factors for atopic dermatitis (AD). The relationship among AD, IV and FLG mutations has not been clarified yet. Mutations 3321delA and K4671X, two of the most common mutations in Chinese patients, were both statistically associated with AD in case-control studies. MATERIALS AND METHODS:...
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