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Article

Genetic polymorphisms of multiple DNA repair pathways impact age at diagnosis and TP53 mutations in breast cancer.

Carcinogenesis - 1 Sept 2011

Smith Tasha R, Liu-Mares Wen, Van Emburgh Beth O, Levine Edward A, Allen Glenn O, Hill Jeff W, Reis Isildinha M, Kresty Laura A, Pegram Mark D, Miller Mark S, Hu Jennifer J

Abstract excerpt

Defective DNA repair may contribute to early age and late stage at time of diagnosis and mutations in critical tumor suppressor genes, such as TP53 in breast cancer. Using DNA samples from 436 breast cancer cases (374 Caucasians and 62 African-Americans), we tested these associations with 18 non-synonymous single-nucleotide polymorphisms (nsSNPs) in four DNA repair pathways: (i) base excision repair: ADPRT V762A,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to X-ray Repair Cross Complementing Protein 1

Source

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Identifiers

PMID: 21700777
DOI: 10.1093/carcin/bgr117
PMCID: PMC3165125

Genes

XPC
ERCC2
ERCC4
MSH6
XRCC1
ERCC5
MLH1
MSH3
POLD1
XRCC3

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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