Article
In vitro megakaryocyte differentiation and proplatelet formation in Ph-negative classical myeloproliferative neoplasms: distinct patterns in the different clinical phenotypes.
PloS one - 1 Jan 2011
Balduini Alessandra, Badalucco Stefania, Pugliano Maria Teresa, Baev Denis, De Silvestri Annalisa, Cattaneo Marco, Rosti Vittorio, Barosi Giovanni
Abstract excerpt
BACKGROUND: Ph-negative myeloproliferative neoplasms (MPNs) are clonal disorders that include primary myelofibrosis (PMF), polycythemia vera (PV) and essential thrombocythemia (ET). Although the pathogenesis of MPNs is still incompletely understood, an involvement of the megakaryocyte lineage is a distinctive feature. METHODOLOGY/PRINCIPAL FINDINGS: We analyzed the in vitro megakaryocyte differentiation and...
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