Article
Proinflammatory phenotype of iPS cell-derived JAK2 V617F megakaryocytes induces fibrosis in 3D in vitro bone marrow niche.
Stem cell reports - 13 Feb 2024
Flosdorf Niclas, Böhnke Janik, de Toledo Marcelo A S, Lutterbach Niklas, Lerma Vanesa Gómez, Graßhoff Martin, Olschok Kathrin, Gupta Siddharth, Tharmapalan Vithurithra, Schmitz Susanne, Götz Katrin, Schüler Herdit M, Maurer Angela, Sontag Stephanie, Küstermann Caroline, Seré Kristin, Wagner Wolfgang, Costa Ivan G, Brümmendorf Tim H, Koschmieder Steffen, Chatain Nicolas, Castilho Miguel, Schneider Rebekka K, Zenke Martin
Abstract excerpt
The myeloproliferative disease polycythemia vera (PV) driven by the JAK2 V617F mutation can transform into myelofibrosis (post-PV-MF). It remains an open question how JAK2 V617F in hematopoietic stem cells induces MF. Megakaryocytes are major players in murine PV models but are difficult to study in the human setting. We generated induced pluripotent stem cells (iPSCs) from JAK2 V617F PV patients and...
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