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Article

Bone marrow megakaryocytic activation predicts fibrotic evolution of Philadelphia-negative myeloproliferative neoplasms.

Haematologica - 1 Dec 2021

Schino Mattia, Fiorentino Vincenzo, Rossi Elena, Betti Silvia, Di Cecca Monica, Ranucci Valentina, Chiusolo Patrizia, Martini Maurizio, De Stefano Valerio, Larocca Luigi Maria

Abstract excerpt

Philadelphia-negative chronic myeloproliferative neoplasms (MPN) have been traditionally considered as indistinctly slowly progressing conditions; recent evidence proves that a subset of cases have a rapid evolution, so that MPN prognosis needs to be personalized. We identified a new morphological parameter, defined as megakaryocytic activation (M-ACT) based on the coexistence of megakaryocytic emperipolesis,...

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Identifiers

PMID: 33543865
DOI: 10.3324/haematol.2020.264143
PMCID: PMC8634198

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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