Article

Systems-level analysis identifies key regulators driving epileptogenesis in temporal lobe epilepsy

2019-07-02

Abstract excerpt

Temporal lobe epilepsy (TLE) is the most prevalent and often devastating form of epilepsy. The molecular mechanism underlying the development of TLE remains largely unknown, which hinders the discovery of effective anti-epileptogenic drugs. In this study, we built a systems-level analytic framework which integrates gene meta-signatures, gene coexpression network and cellular regulatory network to unveil the evolut...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: c64d49f2-1537-5586-835e-dcdae79a3d43
DOI: 10.1101/688069

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Systems-level analysis identifies key regulators driving epileptogenesis in temporal lobe epilepsyDOI 10.1101/688069Read

Identification of gene regulatory networks affected across drug-resistant epilepsiesSemantic proximity Read

Integrative analysis of epilepsy-associated genes reveals expression-phenotype correlations.Semantic proximity Read

Hippocampal CA3 Transcriptional Modules Associated with Granule Cell Alterations and Cognitive Impairment in Refractory Mesial Temporal Lobe Epilepsy PatientsSemantic proximity Read

A Systems Approach Identifies Enhancer of Zeste Homolog 2 (EZH2) as a Protective Factor in EpilepsySemantic proximity Read

Rare and common epilepsies converge on a shared gene regulatory network providing opportunities for novel antiepileptic drug discovery.Semantic proximity Read

Combined transcriptomics and proteomics forecast analysis for potential biomarker in the acute phase of temporal lobe epilepsySemantic proximity Read

Bioinformatic analysis identifies key transcriptome signatures in temporal lobe epilepsySemantic proximity Read

Integrative Analysis of Epilepsy-Associated Genes Reveals Expression-Phenotype CorrelationsSemantic proximity Read

Identification of dysregulated transcription factor activity in temporal lobe epilepsySemantic proximity Read

Pharmacogenomic Analysis of Medial Temporal Lobe Epilepsy with Hippocampal Sclerosis in Humans and Animal ModelsSemantic proximity Read

A systems level, functional genomics analysis of chronic epilepsy.Semantic proximity Read

Prioritization of epileptogenic-associated genes through comparative transcriptome analysesSemantic proximity Read