Article
Genetic determination of human facial morphology: links between cleft-lips and normal variation.
European journal of human genetics : EJHG - 1 Nov 2011
Boehringer Stefan, van der Lijn Fedde, Liu Fan, Günther Manuel, Sinigerova Stella, Nowak Stefanie, Ludwig Kerstin U, Herberz Ruth, Klein Stefan, Hofman Albert, Uitterlinden Andre G, Niessen Wiro J, Breteler Monique M B, van der Lugt Aad, Würtz Rolf P, Nöthen Markus M, Horsthemke Bernhard, Wieczorek Dagmar, Mangold Elisabeth, Kayser Manfred
Abstract excerpt
Recent genome-wide association studies have identified single nucleotide polymorphisms (SNPs) associated with non-syndromic cleft lip with or without cleft palate (NSCL/P), and other previous studies showed distinctly differing facial distance measurements when comparing unaffected relatives of NSCL/P patients with normal controls. Here, we test the hypothesis that genetic loci involved in NSCL/P also influence...
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