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Leveraging the genetics of human face shape boosts the discovery of orofacial cleft risk loci

22 Jul 2026

Abstract excerpt

Several lines of evidence suggest that normal-range facial features and nonsyndromic orofacial clefts (OFCs) exhibit a shared genetic basis. Approaches designed to leverage this relationship hold the possibility of revealing new OFC risk loci by boosting discovery power. To test this idea, we applied a pleiotropy-informed genome-wide association study (GWAS) method (conditional false discovery rate [cFDR]-GWAS)...

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PMID: 42482381
DOI: 10.1016/j.xhgg.2026.100655

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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