Article

Leveraging the genetics of human face shape boosts the discovery of orofacial cleft risk loci

2026-02-03

Abstract excerpt

Several lines of evidence suggest that normal-range facial features and nonsyndromic orofacial clefts (OFCs) exhibit a shared genetic basis. Approaches designed to leverage this relationship hold the possibility of revealing new OFC risk loci by boosting discovery power. To test this idea, we applied a pleiotropy-informed GWAS method (cFDR-GWAS) with summary statistics from large, independent European GWASs of nor...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: cb9741d2-7627-5600-9ce7-ce423f04f51d
DOI: 10.64898/2026.01.30.26345139

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Leveraging the genetics of human face shape boosts the discovery of orofacial cleft risk lociDOI 10.64898/2026.01.30.26345139Read

Leveraging the genetics of human face shape boosts the discovery of orofacial cleft risk lociSemantic proximity Read

Pleiotropy method reveals genetic overlap between orofacial clefts at multiple novel loci from GWAS of multi-ethnic trios.Semantic proximity Read

Insights into the genetic architecture of the human faceSemantic proximity Read

Trio-based GWAS reveals novel loci associated with different forms of isolated cleft lipSemantic proximity Read

Novel genetic loci affecting facial shape variation in humans.Semantic proximity Read

Identifying Genetic Sources of Phenotypic Heterogeneity in Orofacial Clefts by Targeted Sequencing.Semantic proximity Read

Genome-wide analyses of non-syndromic cleft lip with palate identify 14 novel loci and genetic heterogeneity.Semantic proximity Read

Novel genetic loci affecting facial shape variation in humansSemantic proximity Read

Genome-wide mapping of global-to-local genetic effects on human facial shape.Semantic proximity Read

A systematic genetic analysis and visualization of phenotypic heterogeneity among orofacial cleft GWAS signalsSemantic proximity Read

A systematic genetic analysis and visualization of phenotypic heterogeneity among orofacial cleft GWAS signals.Semantic proximity Read

Genome-wide association study of multiethnic non-syndromic orofacial cleft families identifies novel loci specific to family and phenotypic subtypesSemantic proximity Read