Article
Investigating the shared genetics of non-syndromic cleft lip/palate and facial morphology.
PLoS genetics - 1 Aug 2018
Howe Laurence J, Lee Myoung Keun, Sharp Gemma C, Davey Smith George, St Pourcain Beate, Shaffer John R, Ludwig Kerstin U, Mangold Elisabeth, Marazita Mary L, Feingold Eleanor, Zhurov Alexei, Stergiakouli Evie, Sandy Jonathan, Richmond Stephen, Weinberg Seth M, Hemani Gibran, Lewis Sarah J
Abstract excerpt
There is increasing evidence that genetic risk variants for non-syndromic cleft lip/palate (nsCL/P) are also associated with normal-range variation in facial morphology. However, previous analyses are mostly limited to candidate SNPs and findings have not been consistently replicated. Here, we used polygenic risk scores (PRS) to test for genetic overlap between nsCL/P and seven biologically relevant facial...
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