Article
Glioblastoma-derived epidermal growth factor receptor carboxyl-terminal deletion mutants are transforming and are sensitive to EGFR-directed therapies.
Cancer research - 15 Dec 2011
Cho Jeonghee, Pastorino Sandra, Zeng Qing, Xu Xiaoyin, Johnson William, Vandenberg Scott, Verhaak Roel, Cherniack Andrew D, Watanabe Hideo, Dutt Amit, Kwon Jihyun, Chao Ying S, Onofrio Robert C, Chiang Derek, Yuza Yuki, Kesari Santosh, Meyerson Matthew
Abstract excerpt
Genomic alterations of the epidermal growth factor receptor (EGFR) gene play a crucial role in pathogenesis of glioblastoma multiforme (GBM). By systematic analysis of GBM genomic data, we have identified and characterized a novel exon 27 deletion mutation occurring within the EGFR carboxyl-terminus domain (CTD), in addition to identifying additional examples of previously reported deletion mutations in this...
Topics
- Animals
- Antibodies, Monoclonal
- Antibodies, Monoclonal, Humanized
- Antineoplastic Agents
- Brain Neoplasms
- Cell Line
- Cell Line, Tumor
- Cell Proliferation
- Cell Transformation, Neoplastic