Article
Region-specific detection of neuroblastoma loss of heterozygosity at multiple loci simultaneously using a SNP-based tag-array platform.
Genome research - 1 Aug 2005
Maris John M, Hii George, Gelfand Craig A, Varde Shobha, White Peter S, Rappaport Eric, Surrey Saul, Fortina Paolo
Abstract excerpt
Many cancers are characterized by chromosomal aberrations that may be predictive of disease outcome. Human neuroblastomas are characterized by somatically acquired copy number changes, including loss of heterozygosity (LOH) at multiple chromosomal loci, and these aberrations are strongly associated with clinical phenotype including patient outcome. We developed a method to assess region-specific LOH by genotyping...
Topics
- Humans
- Loss of Heterozygosity
- Nervous System Neoplasms
- Neuroblastoma
- Oligonucleotide Array Sequence Analysis
- Polymorphism, Single Nucleotide
- Reference Values
- Sensitivity and Specificity
- Tumor Cells, Cultured