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Article

Beclin 1 deficiency is associated with increased hypoxia-induced angiogenesis

30 Jun 2011

Abstract excerpt

Beclin 1, a tumor suppressor protein, acts as an initiator of autophagy in mammals. Heterozygous disruption of Beclin 1 accelerates tumor growth, but the underlying mechanisms remain unclear. We examined the role of Beclin 1 in tumor proliferation and angiogenesis, using a primary mouse melanoma tumor model. Beclin 1 (Becn1 (+/-) ) hemizygous mice displayed an aggressive tumor growth phenotype with increased...

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PMID: 21685724
DOI: 10.4161/auto.7.8.15598

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