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Article

Genetic overexpression of COMP-Ang1 impairs BM microenvironment and induces senescence of BM HSCs.

Biochemical and biophysical research communications - 15 May 2018

Kook Sung-Ho, Sim Hyun-Jaung, Hwang Jae-Won, Baek Young-Hyun, Kim Chun-Chu, Lee Jeong-Hoon, Cho Eui-Sic, Lee Jeong-Chae

Abstract excerpt

Supplemental Angiopoietin 1 (Ang1) exerts its therapeutic potential on microvascular regression-associated diseases, and this potential is linked with the function of hematopoietic stem cells (HSCs). However, the underlying mechanisms of the effect of enhanced angiogenesis on the modulation of HSCs are not yet defined. Here, we generated transgenic mice expressing Cartilage Oligomeric Matrix Protein (COMP)-Ang1...

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Source

Identifiers

PMID: 29604278
DOI: 10.1016/j.bbrc.2018.03.210

Genes

COMP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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