Article
Genome-wide association study of smoking behaviours in patients with COPD.
Thorax - 1 Oct 2011
Siedlinski Mateusz, Cho Michael H, Bakke Per, Gulsvik Amund, Lomas David A, Anderson Wayne, Kong Xiangyang, Rennard Stephen I, Beaty Terri H, Hokanson John E, Crapo James D, Silverman Edwin K
Abstract excerpt
Background Cigarette smoking is a major risk factor for chronic obstructive pulmonary disease (COPD) and COPD severity. Previous genome-wide association studies (GWAS) have identified numerous single nucleotide polymorphisms (SNPs) associated with the number of cigarettes smoked per day (CPD) and a dopamine beta-hydroxylase (DBH) locus associated with smoking cessation in multiple populations. Objective To...
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