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Structural basis of the monkeypox virus mRNA cap N7 methyltransferase complex

14 Jun 2024

Abstract excerpt

The global outbreak of Mpox, caused by the monkeypox virus (MPXV), has attracted international attention and become another major infectious disease event after COVID-19. The mRNA cap N7 methyltransferase (RNMT) of MPXV methylates the N7 position of the added guanosine to the 5'-cap structure of mRNAs and plays a vital role in evading host antiviral immunity. MPXV RNMT is composed of the large subunit E1 and the...

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PMID: 38873898
DOI: 10.1080/22221751.2024.2369193

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