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Article

Intracellular organization of herpes simplex virus type 1 DNA assayed by staphylococcal nuclease sensitivity.

Virus research - 1 Jul 1990

Lentine A F, Bachenheimer S L

Abstract excerpt

The nucleoprotein organization of herpes simplex virus type 1 (HSV-1) DNA during productive infection was analyzed using staphylococcal nuclease. Both prior to and during the genome replication phase of infection, digestion of nuclei revealed two readily discernible forms of viral DNA, resistant and sensitive. The identity of these forms was established by the use of a variety of assays, including velocity...

Topics

Capsid
Centrifugation, Density Gradient
DNA Replication
DNA, Viral
Deoxyribonucleases
Electrophoresis, Agar Gel
Genes, Viral
Mutation
Nucleosomes
Simplexvirus
Staphylococcus

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Identifiers

PMID: 2168112
DOI: 10.1016/0168-1702(90)90053-e

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2168112-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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