Article
Sensitivity to ionising radiation of transformed human cells containing mutant ras genes.
Oncogene - 1 Aug 1990
Grant M L, Bruton R K, Byrd P J, Gallimore P H, Steele J C, Taylor A M, Grand R J
Abstract excerpt
Measurement of colony forming ability following exposure to gamma-rays has been performed on human retinoblasts transformed with either adenovirus 5 or 12 early region 1 DNA, adenovirus early region 1A plus activated N- or H-ras DNA or SV40 DNA. In contrast to recently reported results (M.D. Sklar, 1988, Science, 239, 645-647), we found no general correlation between transformation with activated ras and...
Topics
- Adenovirus Early Proteins
- Cell Survival
- Cell Transformation, Neoplastic
- Gamma Rays
- Genes, ras
- Humans
- Mutation
- Oncogene Proteins, Viral
- Radiation Tolerance
- Simian virus 40