Article
Identification of a quantitative trait locus for spontaneous osteoarthritis in STR/ort mice.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society - 1 Jan 2012
Watanabe Ken, Oue Yasuhiro, Miyamoto Yoshinari, Matsuura Makiko, Mizuno Yusuke, Ikegawa Shiro
Abstract excerpt
Osteoarthritis (OA) is the most common joint disorder in humans. Most of the animal models of OA were developed by surgical destabilization of joints or through transgenic approaches, and information from naturally occurring models of OA is very limited. The mouse strain STR/ort is recognized as a spontaneous model of OA. This mouse is unique in that it develops late onset cartilage degeneration of the...
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