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Article

Caenorhabditis elegans TRPV ion channel regulates 5HT biosynthesis in chemosensory neurons.

Development (Cambridge, England) - 1 Apr 2004

Zhang Shenyuan, Sokolchik Irina, Blanco Gabriela, Sze Ji Ying

Abstract excerpt

Serotonin (5HT) is a pivotal signaling molecule that modulates behavioral and endocrine responses to diverse chemical and physical stimuli. We report cell-specific regulation of 5HT biosynthesis by transient receptor potential V (TRPV) ion channels in C. elegans. Mutations in the TRPV genes osm-9 or ocr-2 dramatically downregulate the expression of the gene encoding the 5HT synthesis enzyme tryptophan hydroxylase...

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PMID: 14998926
DOI: 10.1242/dev.01047

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OSM

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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