Article
Generation of antitumor response by IL-2-transduced JAWS II dendritic cells.
Immunobiology - 1 Oct 2011
Rossowska Joanna, Pajtasz-Piasecka Elżbieta, Ryśnik Oliwia, Wojas Justyna, Krawczenko Agnieszka, Szyda Anna, Duś Danuta
Abstract excerpt
Antigen-loaded dendritic cells (DCs) are a promising tool for inducing a tumor-specific immune response. It seems probable that co-administration of those cells together with cytokine-transduced DCs can further increase effectiveness of the antitumor vaccine. The local production of IL-2 by genetically modified DCs may result in alteration of the unfavorable tumor environment causing immune response dysfunction....
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