Assessing the contribution family data can make to case-control studies of rare variants.

doi:10.1111/j.1469-1809.2011.00660.x

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Article

Assessing the contribution family data can make to case-control studies of rare variants.

Annals of human genetics - 1 Sept 2011

Curtis David

Abstract excerpt

When pathogenic variants are rare then even among cases the proportion of subjects possessing a variant might be low, meaning that very large samples might be required to conclusively demonstrate evidence of an effect. Relatives of subjects within a case-control sample might provide useful additi...

Topics

Case-Control Studies
Family
Genetic Linkage
Genetic Predisposition to Disease
Humans
Linkage Disequilibrium
Models, Statistical
Pedigree
Research Design
Siblings

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