Article
Chemokine (C-C motif) receptor 5 -2459 genotype in patients receiving highly active antiretroviral therapy: race-specific influence on virologic success.
The Journal of infectious diseases - 15 Jul 2011
Mehlotra Rajeev K, Cheruvu Vinay K, Blood Zikursh Melinda J, Benish Rebekah L, Lederman Michael M, Salata Robert A, Gripshover Barbara, McComsey Grace A, Lisgaris Michelle V, Fulton Scott, Subauste Carlos S, Jurevic Richard J, Guillemette Chantal, Zimmerman Peter A, Rodriguez Benigno
Abstract excerpt
BACKGROUND: In patients receiving highly active antiretroviral therapy (HAART), antiretroviral drug-metabolizing enzyme and transporter gene polymorphisms, as well as chemokine receptor gene polymorphisms, may influence response to treatment. METHODS: In a North American, treated, adherent human immunodeficiency virus (HIV)-positive cohort (self-identified whites, n = 175; blacks, n = 218), we investigated...
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