Article
Effect of chemokine receptor gene polymorphisms on the response to potent antiretroviral therapy.
AIDS (London, England) - 5 May 2000
O'Brien T R, McDermott D H, Ioannidis J P, Carrington M, Murphy P M, Havlir D V, Richman D D
Abstract excerpt
BACKGROUND: Both the natural history of HIV infection and the response to antiretroviral therapy are heterogeneous. Polymorphisms in chemokine receptor genes modulate the natural history of HIV-1 infection. In comparison with subjects with other genotypes, the prognosis for HIV-1-infected CCR5-delta32 heterozygotes is more favorable and that for CCR5 promoter allele 59029A homozygotes is less favorable. METHODS:...
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