Article
Role of the novel Th17 cytokine IL-17F in inflammatory bowel disease (IBD): upregulated colonic IL-17F expression in active Crohn's disease and analysis of the IL17F p.His161Arg polymorphism in IBD.
Inflammatory bowel diseases - 1 Apr 2008
Seiderer Julia, Elben Ira, Diegelmann Julia, Glas Jürgen, Stallhofer Johannes, Tillack Cornelia, Pfennig Simone, Jürgens Matthias, Schmechel Silke, Konrad Astrid, Göke Burkhard, Ochsenkühn Thomas, Müller-Myhsok Bertram, Lohse Peter, Brand Stephan
Abstract excerpt
BACKGROUND: Interleukin (IL)-17F, produced in IL-23R-expressing Th17 cells, is a novel member of the IL-17 cytokine family. Given the association of IL23R with inflammatory bowel disease (IBD), we characterized the role of IL-17F in IBD including its intestinal gene expression and the effect of the IL17F p.His161Arg polymorphism on disease susceptibility and phenotype of Crohn's disease (CD) and ulcerative...
Topics
- Adolescent
- Adult
- Aged
- Aged, 80 and over
- Child
- Colitis, Ulcerative
- Colon
- Crohn Disease
- Epistasis, Genetic