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Article

Impact of Genetics on Mature Lymphoid Leukemias and Lymphomas.

Cold Spring Harbor perspectives in medicine - 2 Nov 2020

Bailey Nathanael G, Elenitoba-Johnson Kojo S J

Abstract excerpt

Recurrent genetic aberrations have long been recognized in mature lymphoid leukemias and lymphomas. As conventional karyotypic and molecular cloning techniques evolved in the 1970s and 1980s, multiple cytogenetic aberrations were identified in lymphomas, often balanced translocations that juxtaposed oncogenes to the immunoglobulin (IG) or T-cell receptor (TR) loci, leading to dysregulation. However, genetic...

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Identifiers

PMID: 31932467
DOI: 10.1101/cshperspect.a035444
PMCID: PMC7605231

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