Article
Infection with adeno-associated virus type 5 inhibits mutagenicity of herpes simplex virus type 1 or 4-nitroquinoline-1-oxide.
Mutation research - 1 Aug 1990
Schlehofer J R, Heilbronn R
Abstract excerpt
Infection with adeno-associated virus type 5 (AAV-5) reduced the number of mutants arising in the hypoxanthine phosphoribosyltransferase locus of human RD 176 cells after infection with herpes simplex virus type 1 (HSV-1; partially inactivated) or 4-nitroquinoline-1-oxide (4-NQO). The mutation frequency was reduced by AAV-5 infection from 11.4 to 1.8 after mutation with HSV-1 and from 3.2 to 2.5 when mutation was...
Topics
- 4-Nitroquinoline-1-oxide
- Azaguanine
- Dependovirus
- Drug Resistance
- Humans
- Hypoxanthine Phosphoribosyltransferase
- Mutagenicity Tests
- Mutation
- Nitroquinolines
- Simplexvirus
- Tumor Cells, Cultured