Properties of a 9-(2-phosphonylmethoxyethyl)adenine (PMEA)-resistant herpes simplex virus type 1 virus mutant.

doi:10.1016/0166-3542(90)90049-d

Back to search

Article

Properties of a 9-(2-phosphonylmethoxyethyl)adenine (PMEA)-resistant herpes simplex virus type 1 virus mutant.

Antiviral research - 1 Aug 1990

Vonka V, Anisimová E, Cerný J, Holý A, Rosenberg I, Votruba I

Abstract excerpt

After repeated passages of herpes simplex type 1 (HSV-1) KOS virus in the presence of 9-(2-phosphonylmethoxyethyl)adenine (PMEA) a mutant denoted PMEAr HSV-1 was isolated which grew well in the presence of 50-100 micrograms.ml-1 of the drug. PMEAr HSV-1 was still sensitive to the related phosphon...

Topics

Acyclovir
Adenine
Animals
Bromodeoxyuridine
Drug Resistance, Microbial
Mutation
Organophosphonates
Organophosphorus Compounds
Simplexvirus
Vero Cells
Virus Replication

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.