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Effective clearance of mouse hepatitis virus from the central nervous system requires both CD4+ and CD8+ T cells

1 Sept 1990

Abstract excerpt

Both CD4+ and CD8+ T cells are required for the clearance of virus from the central nervous system following infection with the JHM strain of mouse hepatitis virus. Development of antiviral antibodies requires the presence of CD4+ T cells but appears to play a minimal role in the reduction of virus. The data presented are consistent with the hypothesis that clearance of JHM virus is mediated by virus-specific...

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PMID: 2166833
DOI: 10.1128/jvi.64.9.4589-4592.1990

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