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Article

Increased Reticulon 3 (RTN3) Leads to Obesity and Hypertriglyceridemia by Interacting With Heat Shock Protein Family A (Hsp70) Member 5 (HSPA5).

Circulation - 23 Oct 2018

Xiang Rong, Fan Liang-Liang, Huang Hao, Chen Ya-Qin, He Wanxia, Guo Shuai, Li Jing-Jing, Jin Jie-Yuan, Du Ran, Yan Riqiang, Xia Kun

Abstract excerpt

BACKGROUND: Reticulon 3 (RTN3) is an endoplasmic reticulum protein that has previously been shown to play a role in neurodegenerative diseases, but little is known about its role in lipid metabolism. METHODS: Obese patients (n=149), hypertriglyceridemic patients (n=343), and healthy control subjects (n=84) were enrolled to assess their levels of RTN3. To explore the pathophysiological roles of RTN3 in the control...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 29716941
DOI: 10.1161/CIRCULATIONAHA.117.030718
PMCID: PMC6392466

Genes

RTN3
HSPA5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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