Hypothalamic expression of urocortin 3 and the type 2 corticotropin-releasing factor receptor is regulated according to feeding state in lean but not obese Zucker rats.

doi:10.1016/j.neuropharm.2011.12.023

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Article

Hypothalamic expression of urocortin 3 and the type 2 corticotropin-releasing factor receptor is regulated according to feeding state in lean but not obese Zucker rats.

Neuropharmacology - 1 Jul 2012

Poulin Anne-Marie, Lenglos Christophe, Mitra Arojit, Timofeeva Elena

Abstract excerpt

Urocortin 3 (Ucn3) is an anorexigenic neuropeptide with high affinity for the type 2 corticotropin-releasing factor receptor (CRF₂-R). How the expression of hypothalamic Ucn3 is regulated by fasting and refeeding in genetically obese (fa/fa) Zucker rats is not known. Obese Zucker rats develop early hyperphagia associated with low expression of CRF₂-R in the ventromedial hypothalamic nucleus (VMH) in this...

Topics

Analysis of Variance
Animals
Body Weight
Disease Models, Animal
Eating
Food Deprivation
Gene Expression Regulation
Hypothalamus
Male
Obesity
Phenotype

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

RNA, Messenger

Rats

Rats, Zucker

Receptors, Corticotropin-Releasing Hormone

Time Factors

Urocortins

Source

Open in PubMed

Identifiers

PMID: 22227020
DOI: 10.1016/j.neuropharm.2011.12.023

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