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Article

Estimation of parent specific DNA copy number in tumors using high-density genotyping arrays.

PLoS computational biology - 27 Jan 2011

Chen Hao, Xing Haipeng, Zhang Nancy R

Abstract excerpt

Chromosomal gains and losses comprise an important type of genetic change in tumors, and can now be assayed using microarray hybridization-based experiments. Most current statistical models for DNA copy number estimate total copy number, which do not distinguish between the underlying quantities of the two inherited chromosomes. This latter information, sometimes called parent specific copy number, is important...

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PMID: 21298078
DOI: 10.1371/journal.pcbi.1001060
PMCID: PMC3029233

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