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Article

The Amino Terminus of the Human AR Is Target for Corepressor Action and Antihormone Agonism

1 Apr 2002

Abstract excerpt

Antiandrogens inhibit the ligand-induced transactivation by the androgen receptor (AR) and have a widespread use in the treatment of prostate cancer but their mode of action is not fully understood. Here we show that the ability of the antiandrogen cyproterone acetate (CPA) to inhibit transactivation by the human AR (hAR) involves the corepressor SMRT (silencing mediator for retinoic acid and thyroid hormone...

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Identifiers

PMID: 11923464
DOI: 10.1210/mend.16.4.0798

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