Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Influence of short polyglutamine tracts and p160 coactivators on the transactivation of the androgen receptor.

Cancer biotherapy & radiopharmaceuticals - 1 Apr 2011

Shi Xu-Bao, Xue Lingru, Shi Donghua, deVere White Ralph W

Abstract excerpt

The androgen receptor (AR) acting as a transcription factor plays a pivotal role in the occurrence and progression of prostate cancer (CaP). Several AR-related factors or modulators have been reported to influence AR activity. Whether and how these factors cooperatively modulate the AR activity has not been well defined. In the present study, the combined effect of p160 coactivators, short CAG length (encoding a...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Androgen Antagonists
Share to Anilides
Share to Dihydrotestosterone

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Luciferases

Share to Nitriles

Share to Prostatic Neoplasms

Share to Receptors, Androgen

Share to Transcriptional Activation

Source

Open in PubMed Open full text

Identifiers

PMID: 21539451
DOI: 10.1089/cbr.2010.0888
PMCID: PMC3128791

Genes

SRC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Influence of short polyglutamine tracts and p160 coactivators on the transactivation of the androgen receptor.PMID 21539451Read ↗

Corepressor effect on androgen receptor activity varies with the length of the CAG encoded polyglutamine repeat and is dependent on receptor/corepressor ratio in prostate cancer cells.Semantic proximity Read ↗

Inhibition of p160-mediated coactivation with increasing androgen receptor polyglutamine lengthSemantic proximity Read ↗

Mechanisms of androgen receptor signalling via steroid receptor coactivator-1 in prostate.Semantic proximity Read ↗

The A645D mutation in the hinge region of the human androgen receptor (AR) gene modulates AR activity, depending on the context of the polymorphic glutamine and glycine repeats.Semantic proximity Read ↗

The Androgen Receptor Interacts with Multiple Regions of the Large Subunit of General Transcription Factor TFIIFSemantic proximity Read ↗

The Hinge Region Regulates DNA Binding, Nuclear Translocation, and Transactivation of the Androgen ReceptorSemantic proximity Read ↗

A novel prostate cancer therapeutic strategy using icaritin-activated arylhydrocarbon-receptor to co-target androgen receptor and its splice variantsSemantic proximity Read ↗

An investigation into CAG repeat length variation and N/C terminal interactions in the T877A mutant androgen receptor found in prostate cancer.Semantic proximity Read ↗

TAF1 Differentially Enhances Androgen Receptor Transcriptional Activity via Its N-Terminal Kinase and Ubiquitin-Activating and -Conjugating DomainsSemantic proximity Read ↗

GRIP1 mediates the interaction between the amino- and carboxyl-termini of the androgen receptor.Semantic proximity Read ↗

The length and location of CAG trinucleotide repeats in the androgen receptor N-terminal domain affect transactivation function.Semantic proximity Read ↗

A naturally occurring mutation in the human androgen receptor of a subject with complete androgen insensitivity confers binding and transactivation by estradiol.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.